after starting with 20 mg of paroxetine 15 years ago I noticed after a while that it wasn't effective any more, after visiting psychiatrist I was prescribed venlafaxine, initially 150 mg and after a year 225 mg, this has worked well up to now, as far as I'm concerned, despite the known side-effects of antidepressants, I combine the venlafaxine with tranxene 10 mg 3x a day.
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